The 53-year-old actress got candid with the weekly publication while dishing on everything from starring opposite younger male co-stars and preparing for an empty nest.
Highlights from Miss Pfeiffer's interview are as follows. For more, be sure to pay a visit to Parade!
On what drives her to succeed:
"I don?t know if it?s na�vet� or just narcissism, but I start out with this notion that I can do anything. It?s not until I get into it that I realize what I?ve thrown myself into, and then I will do anything not to humiliate myself. And that, I think, is the secret to my success."
On acting opposite younger leading men:
"They get younger and younger. I went from Ashton (Kutcher) to Rupert (Friend) to Zac Efron in New Year?s Eve. If I keep on like this, I?m going to get into X-rated material! Well, that?s what happens with men and their leading ladies, right? I was acting in The Russia House opposite Sean Connery when he was turning 60. [Pfeiffer was 32.]"
On which is harder: parenting or acting:
"Being a parent is the hardest thing in the world ? the psychological toll it takes on you because these lives are in your hands. I take it very seriously. Just when you think you?ve got your kids figured out, they change on you. For somebody who?s controlling, you can?t control it. Of course, I don?t think I?m controlling, but that?s what I?ve been told!"
On preparing for an empty nest:
"People make a lot of jokes about the empty nest. Let me tell you, it is no laughing matter. It is really hard. Claudia?s in her first year of college. She?s doing great. My son is applying to colleges now. I remember reading an interview with Dustin Hoffman; his first child had just gone off to college, and he said, ?Nobody talks about their [empty] room.? I feel like I?m going to cry just thinking about it. [pause] Are you hot? I am. Or am I having a big hot flash? Did I really just say that? That will be a headline; I can see it. [laughs]"